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Thursday, December 1, 2011

Myocardial Infarction (Death Of The Heart Muscle) Stem Cell Treatment Three Times Better Than Anticipated

Myocardial Infarction (Death Of The Heart Muscle) Stem Cell Treatment Three Times Better Than Anticipated


“..8.5 percent improvement just four months following the reintroduction of stem cells and 12 percent after one year.”

“If these results hold up in future studies, I believe this could be the biggest revolution in cardiovascular medicine in my lifetime.”


By Dell Hill

Some incredible stem cell research results are being documented at hospitals around the world.  Today’s report suggests that damaged heart tissue can be repaired, rather than left for “dead”, by use of the patients own stem cells.

Our report comes from Diagnostic and Interventional Cardiology.


“Heart failure patients with a previous myocardial infarction showed an average of 12 percent improvement one year following an investigative treatment that infused them with their own stem cells. The results triple the 4 percent improvement average the researchers projected for the Phase I trial.

Results of the trial have been published in The Lancet and concurrently presented at the American Heart Association Scientific Sessions in Orlando, Fla. They are the first report of administering subjects’ own cardiac stem cells in humans. Previous studies have used stem cells harvested from bone marrow.

The research team, led by Roberto Bolli, M.D., of the University of Louisville and Piero Anversa, M.D., at Brigham and Women’s Hospital/Harvard Medical School in Boston, conducted the SCIPIO trial; SCIPIO is an acronym for “Cardiac Stem Cells in Patients with Ischemic CardiOmyopathy.”

The 16 trial patients were diagnosed with heart failure following a myocardial infarction and had a left ventricular ejection fraction (LVEF) of 40 percent or lower. LVEF is a standard measure of the heart’s pumping capability; it measures how much blood is ejected from the left ventricle during a heartbeat. The normal LVEF is 50 percent or higher.

The investigators harvested cardiac stem cells from the patients during coronary artery bypass surgery conducted at Jewish Hospital in Louisville. Cardiac stem cells are referred to as “c-kit positive” cells because they express the c-kit protein on their surface. They were purified in Anversa’s lab in Boston and allowed to grow. Once an adequate number of stem cells were produced – about one million – Bolli’s team in Louisville reintroduced them into the region of the patient’s heart that had been scarred by the infarction.

In designing the trial, Bolli and Anversa examined data from previous studies of bone marrow-derived stem cells and projected an average improvement in LVEF of 4-5 percent for all patients. They witnessed an 8.5 percent improvement just four months following the reintroduction of stem cells and 12 percent after one year.

The researchers also conducted magnetic resonance imaging (MRI) studies on the patients’ hearts and saw the size of the scarred regions had decreased – a result that seemingly begins to disprove the long-held belief that once scarring occurs, the heart tissue is forever dead.

Bolli – who is lead author of the Lancet article and presenter of the data at the scientific sessions – says the adult stem cell protocol could become one of the greatest advancements in cardiac treatment in a generation.

“The results are striking,” Bolli said. “While we do not yet know why the improvement occurs, we have no doubt now that ejection fraction increased and scarring decreased. If these results hold up in future studies, I believe this could be the biggest revolution in cardiovascular medicine in my lifetime.”

I invite you to read the entire article by clicking right here.

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